Henry Houlden is a neurology professor and the head of the Neurogenetics laboratory at UCL Institute of Neurology’s National Hospital Neurology and Neurosurgery. His research lab specializes in neurodegeneration, peripheral nerve disease and ataxias; offering genetic and neuropathological investigations of human diseases with functional in vitro experiments for human diagnoses.
Houlden has made contributions to several scientific papers, such as:
Early Life and Education
Henry Houlden is a professor at University College London’s MRC Centre for Neuromuscular Diseases in England. He studies genetic causes of severe forms of Charcot-Marie-Tooth disease (CMT), an early-onset neuropathy condition, which could help optimize treatment strategies and speed up new therapy development.
Houlden has extensive clinical and research laboratory experience working on movement disorders related to genetic inheritance such as Multiple System Atrophy (MSA), Ataxia, Leukodystrophy Epilepsy Paroxysmal Conditions Spastic Paraplegia Neuromuscular Conditions as well as risk factors and disease pathways associated with these conditions.
He and his colleagues have utilized genetic and genomic technologies to identify and characterize numerous mutations associated with Alzheimer’s disease, specifically the gene APOE. Their analysis indicates that these mutations cause early-onset Alzheimer’s and contribute to some of its early symptoms.
He conducts laboratory research in neurogenetics and movement disorders with particular interest in rare adult or childhood-onset disorders like multiple system atrophy, spinocerebellar ataxia and other movement disorders, leukodystrophy, epilepsy/paroxysmal conditions/spastic paraplegia/inherited neuromuscular conditions affecting diverse and underrepresented populations – specifically multiple system atrophy, spinocerebellar ataxia/other movement disorders/leukodystrophy/leukodystrophy/leukodystrophy/leukodystrophy/ epilepsy/paroxysmal conditions/ spastic paraplegia/inherited neuromuscular conditions) affecting diverse and underrepresented populations (multiple system atrophy/leukodystrophy/leukodystrophy/leukodystrophy/leukodystrophy/ epilepsy/paroxysmal conditions/spastic paraplegia/inherited neuromuscular conditions/ spastic paraplegia/inherited neuromuscular conditions/spastic paraplegia/inherited neuromuscular conditions). His team integrates new gene discovery with exome sequencing to identify disease genes like CANVAS/ NARS1/NKX-6.2/SCA11/15 GRIA2/GAD1. Functional experimental validation in human tissue/other model systems with functional experimental validation testing against human tissue/other systems with functional experimental validation testing in human tissue/other model systems etc; etc). His team integrates new gene discovery as well as genomic sequencing to identify disease genes such as GAD1/GAD1. His team uses functional experimental validation using functional experimental validation against human tissue/model systems/ AD1 with functional experimental validation testing of tissues using functional experimental validation techniques such as NARS1/NARS1NARS1, NARS1, NARS1, NARS1, NARS1, NARS1 GAD1 etc with functional experimental validation against model systems to demonstrate functional experimental validation used – including functional validation within human tissues or model systems used.
Holden filled in for Holly Willoughby as guest host of This Morning from 22 September to 18 December 2014. Additionally, he co-presented multiple episodes with Phillip Schofield. Holden also has appeared in various TV shows such as BBC comedy drama Big Top and three seasons of ITV show Kiss Me Kate.
Achievement and Honors
Henry Houlden has participated in several scientific research projects and contributed to various journals over his long career, in areas of Genetics, Pathology, Mutation and Disease research. As part of these endeavors he published several papers and books related to these fields of knowledge.
His research laboratory is focused on neurological conditions that run in families, such as multiple system atrophy, spinocerebellar ataxia, ALS/other movement disorders, leukodystrophy epilepsy and spastic paraplegia. Furthermore, genetics/genomics research with an emphasis on discovery of disease genes through exome sequencing and functional genetic studies is undertaken here.
He has been active in multiple professional societies and received several awards for his efforts. Furthermore, he was involved with academic activities as well as serving on several boards of directors and has undertaken humanitarian and civic causes.
Houlden has also done work in the charitable field outside his acting career. He assisted with research for spinocerebellar ataxia, which is a hereditary disorder causing degeneration to parts of the brain that control movement. Houlden assessed patients and family members to discover hitherto unknown ataxia genes that will assist future effective diagnosis.
He is married to Mary Houlden and they share one daughter together. He enjoys golfing and supporting the local cricket team; in England he owns his home where he spends his holidays.
He has been an active member of the Church of England since childhood, as well as being active members of both Royal Society of Chemistry and American Chemical Society. Furthermore, he is an enthusiastic supporter of Arts Council England, having even served on their board in past.